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Pioneer Axon Guidance by UNC-129, a C. elegans TGF-β

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Science  31 Jul 1998:
Vol. 281, Issue 5377, pp. 706-709
DOI: 10.1126/science.281.5377.706

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Abstract

The unc-129 gene, like the unc-6 netrin gene, is required to guide pioneer motoraxons along the dorsoventral axis ofCaenorhabditis elegans. unc-129 encodes a member of the transforming growth factor–β (TGF-β) superfamily of secreted signaling molecules and is expressed in dorsal, but not ventral, rows of body wall muscles. Ectopic expression of UNC-129 from ventral body wall muscle disrupts growth cone and cell migrations that normally occur along the dorsoventral axis. Thus, UNC-129 mediates expression of dorsoventral polarity information required for axon guidance and guided cell migrations in C. elegans.

  • * To whom correspondence should be addressed. E-mail: culotti{at}mshri.on.ca

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