Choosing a Place to Begin

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Science  14 Aug 1998:
Vol. 281, Issue 5379, pp. 929-930
DOI: 10.1126/science.281.5379.929

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In viruses, bacteria, and yeasts, the process of making new DNA to donate to daughter cells begins at specific nucleotide sequences called replicators located within "replication origins." In his Perspective, Huberman describes how after many years of effort this mechanism has finally been extended to animal cells, as reported in a report by Aladjem et al. in this issue.