IEX-1L, an Apoptosis Inhibitor Involved in NF-κB-Mediated Cell Survival

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Science  14 Aug 1998:
Vol. 281, Issue 5379, pp. 998-1001
DOI: 10.1126/science.281.5379.998

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Transcription factors of the nuclear factor–κB/rel (NF-κB) family may be important in cell survival by regulating unidentified, anti-apoptotic genes. One such gene that protects cells from apoptosis induced by Fas or tumor necrosis factor type α (TNF),IEX-1L, is described here. Its transcription induced by TNF was decreased in cells with defective NF-κB activation, rendering them sensitive to TNF-induced apoptosis, which was abolished by transfection with IEX-1L. In support, overexpression of antisense IEX-1L partially blocked TNF-induced expression ofIEX-1L and sensitized normal cells to killing. This study demonstrates a key role of IEX-1L in cellular resistance to TNF-induced apoptosis.

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