Special Reviews

Death Receptors: Signaling and Modulation

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Science  28 Aug 1998:
Vol. 281, Issue 5381, pp. 1305-1308
DOI: 10.1126/science.281.5381.1305

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Abstract

REVIEW

Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery.

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