Special Reviews

Mitochondria and Apoptosis

Science  28 Aug 1998:
Vol. 281, Issue 5381, pp. 1309-1312
DOI: 10.1126/science.281.5381.1309

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Abstract

REVIEW

A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins. The different signals that converge on mitochondria to trigger or inhibit these events and their downstream effects delineate several major pathways in physiological cell death.

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