PerspectiveSignal Transduction

Routing MAP Kinase Cascades

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Science  11 Sep 1998:
Vol. 281, Issue 5383, pp. 1625-1626
DOI: 10.1126/science.281.5383.1625

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Summary

Cells need to convey information from signals on their surface to a variety of intracellular targets, including transcription factors, contractile proteins, and enzymes. To do so efficiently, they construct information pathways with enzymes called kinases, using the same enzymes over and over. But what prevents cross talk between pathways? In her Perspective, Elion discusses new results in this issue by Whitmarsh et al. and Schaeffer et al., who identify proteins that act as scaffolds in mouse cells, binding certain kinases to make a pathway for a specific function that is insulated from the rest of the cell.