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More SNPs on the Way

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Science  18 Sep 1998:
Vol. 281, Issue 5384, pp. 1788
DOI: 10.1126/science.281.5384.1788

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Late last year, the National Cancer Institute (NCI) launched a project to find genome markers called single-nucleotide polymorphisms, or SNPs, to use in tracking down the hundreds of genes thought to affect cancer risk. NCI has already put about $1 million into the project, called the Genetic Annotation Initiative, which began generating SNPs in the spring. Researchers running the initiative are hoping that their approach, which involves identifying several SNPs in and around the coding regions of genes already thought to be involved in cancer risk, will avoid many of the problems in using SNPs discussed at a recent conference in Skokloster, Sweden (see main text).