Genetic Variation as a Guide to Drug Development

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Science  18 Sep 1998:
Vol. 281, Issue 5384, pp. 1820-1821
DOI: 10.1126/science.281.5384.1820

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In Techview for September, Kleyn and Vesell discuss the field of pharmacogenomics, which uses large-scale genetic techniques to pursue drug development. Disease risk, drug resistance, and slow drug clearance are all known to be associated with particular genes. The authors review the methods for searching the human genome that may reveal connections between genetic variations and drug effectiveness and safety.