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Semiconductor Nanocrystals as Fluorescent Biological Labels

Science  25 Sep 1998:
Vol. 281, Issue 5385, pp. 2013-2016
DOI: 10.1126/science.281.5385.2013

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Abstract

Semiconductor nanocrystals were prepared for use as fluorescent probes in biological staining and diagnostics. Compared with conventional fluorophores, the nanocrystals have a narrow, tunable, symmetric emission spectrum and are photochemically stable. The advantages of the broad, continuous excitation spectrum were demonstrated in a dual-emission, single-excitation labeling experiment on mouse fibroblasts. These nanocrystal probes are thus complementary and in some cases may be superior to existing fluorophores.

  • * To whom correspondence should be addressed. E-mail: sweiss{at}mhl.lbl.gov and alivis{at}uclink4.berkeley.edu

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