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Dorsal-Ventral Signaling in the Drosophila Eye

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Science  25 Sep 1998:
Vol. 281, Issue 5385, pp. 2031-2034
DOI: 10.1126/science.281.5385.2031

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Abstract

The development of the Drosophila eye has served as a model system for investigations of tissue patterning and cell-cell communication; however, early eye development has not been well understood. The results presented here indicate that specialized cells are established along the dorsal-ventral midline of the developing eye by Notch-mediated signaling between dorsal and ventral cells, and that Notch activation at the midline plays an essential role both in promoting the growth of the eye primordia and in regulating eye patterning. These observations imply that the developmental homology between Drosophila wings and vertebrate limbs extends toDrosophila eyes.

  • * To whom correspondence should be addressed. E-mail: irvine{at}mbcl.rutgers.edu

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