Role of Farnesyltransferase in ABA Regulation of Guard Cell Anion Channels and Plant Water Loss

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Science  09 Oct 1998:
Vol. 282, Issue 5387, pp. 287-290
DOI: 10.1126/science.282.5387.287

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Desiccation of plants during drought can be detrimental to agricultural production. The phytohormone abscisic acid (ABA) reduces water loss by triggering stomatal pore closure in leaves, a process requiring ion-channel modulation by cytoplasmic proteins. Deletion of the Arabidopsis farnesyltransferase geneERA1 or application of farnesyltransferase inhibitors resulted in ABA hypersensitivity of guard cell anion-channel activation and of stomatal closing. ERA1 was expressed in guard cells. Double-mutant analyses of era1 with the ABA-insensitive mutants abi1 and abi2 showed that era1suppresses the ABA-insensitive phenotypes. Moreover, era1plants exhibited a reduction in transpirational water loss during drought treatment.

  • * To whom correspondence should be addressed at Department of Biology, University of California, San Diego, La Jolla, CA 92093–0116, USA. E-mail: julian{at}

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