Two Modes of Survival of Fission Yeast Without Telomerase

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Science  16 Oct 1998:
Vol. 282, Issue 5388, pp. 493-496
DOI: 10.1126/science.282.5388.493

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Deletion of the telomerase catalytic subunit genetrt1 + in Schizosaccharomyces pombe results in death for the majority of cells, but a subpopulation survives. Here it is shown that most survivors have circularized all of their chromosomes, whereas a smaller number maintain their telomeres presumably through recombination. When the telomeric DNA-binding gene taz1 + is also deleted, trt1 taz1 survivors use the recombinational mode more frequently. Moreover, the massive elongation of telomeres in taz1 cells is absent in the double mutant. Thus, Taz1p appears to regulate telomeric recombination as well as telomerase activity in fission yeast.

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