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From Fat-Free Mice, the Skinny on Diabetes

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Science  23 Oct 1998:
Vol. 282, Issue 5389, pp. 604
DOI: 10.1126/science.282.5389.604a

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It has long been known that obesity plays a role in diabetes, although endocrinologists don't know exactly how. Now two independent groups have shown that mice genetically engineered to lack fat cells also get diabetes, with symptoms--high blood sugar and insulin levels and a ferocious thirst and appetite--even more severe than those of their obese counterparts. Reported in last week's issue of Genes and Development, the findings may yield clues to the enigma of adult-onset diabetes, also called type 2 diabetes or diabetes mellitus.