The Causes of Haldane's Rule

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Science  30 Oct 1998:
Vol. 282, Issue 5390, pp. 889-891
DOI: 10.1126/science.282.5390.889

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How do new species form? A clue comes from the ubiquitous Haldane's rule, which predicts that when offspring of a mating between different animal species display sterility or inviability in one sex only, the afflicted sex has sex chromosomes of different types. In his Perspective, Turelli explains how new results presented in this issue by Presgraves and Orr explain how both of the major hypotheses explaining Haldane's rule are correct.