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TNF-α Induction of CD44-Mediated Leukocyte Adhesion by Sulfation

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Science  30 Oct 1998:
Vol. 282, Issue 5390, pp. 941-943
DOI: 10.1126/science.282.5390.941

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Abstract

Regulation of cell adhesion is important for immune system function. CD44 is a tightly regulated cell adhesion molecule present on leukocytes and implicated in their attachment to endothelium during an inflammatory immune response. The proinflammatory cytokine tumor necrosis factor–α, but not interferon-γ, was found to convert CD44 from its inactive, nonbinding form to its active form by inducing the sulfation of CD44. This posttranslational modification was required for CD44-mediated binding to the extracellular matrix component hyaluronan and to vascular endothelial cells. Sulfation is thus a potential means of regulating CD44-mediated leukocyte adhesion at inflammatory sites.

  • * Present address: Section of Bone Marrow Transplantation, Rush Presbyterian–St. Luke's Medical Center, Chicago, IL 60612, USA.

  • To whom correspondence should be addressed. E-mail: pauline{at}unixg.ubc.ca

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