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Chromosome 2 Sequence of the Human Malaria Parasite Plasmodium falciparum

Science  06 Nov 1998:
Vol. 282, Issue 5391, pp. 1126-1132
DOI: 10.1126/science.282.5391.1126

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Abstract

Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with the Saccharomyces cerevisiaegenome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A+T-rich P. falciparum genome is technically feasible.

  • * Present address: ARIAD Pharmaceuticals, 26 Landsdowne Street, Cambridge, MA 02139, USA.

  • Present address: Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA.

  • To whom correspondence should be addressed. E-mail: hoffmans{at}nmripo.nmri.nnmc.navy.mil

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