Control of Neonatal Tolerance to Tissue Antigens by Peripheral T Cell Trafficking

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Science  13 Nov 1998:
Vol. 282, Issue 5392, pp. 1338-1341
DOI: 10.1126/science.282.5392.1338

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Self tolerance is acquired by the developing immune system. As reported here, particular properties of the neonatal tissue contribute to this process. Neonatal skin, but not adult skin, was accessible for naı̈ve CD8 T cells. In mouse bone marrow chimeras generated at different ages, recent thymic emigrants were tolerized to a skin-expressed major histocompatibility complex class I antigen only during a neonatal period but not during adulthood. Blockade of T cell migration neonatally prevented tolerance induction. Thus, T cell trafficking through nonlymphoid tissues in the neonate is crucial for the establishment of self tolerance to sessile, skin-expressed antigens.

  • * Present address: Ontario Cancer Institute/Amgen Institute, Toronto, Ontario M5G 2C1, Canada.

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