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Can IL-2 Smoke Out HIV Reservoirs?

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Science  20 Nov 1998:
Vol. 282, Issue 5393, pp. 1394-1395
DOI: 10.1126/science.282.5393.1394b

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NEW DELHI-- Although potent cocktails of anti-HIV drugs can knock the virus back to undetectable levels in patients' blood, HIV continues to lurk in "reservoirs"--cells that harbor the virus where antivirals cannot get at it. Now, new studies by a team at the National Institute of Allergy and Infectious Diseases indicate that a natural immune system regulatory molecule called interleukin-2, if given to patients along with combination therapy, can flush HIV from at least one reservoir out into the open. The finding, reported at the International Congress of Immunology here earlier this month, raises hope that it may one day be possible to rid people of HIV entirely.