Tech.SightLIGAND BINDING

Molecular Barbells

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Science  20 Nov 1998:
Vol. 282, Issue 5393, pp. 1439
DOI: 10.1126/science.282.5393.1439

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Summary

Dimers linked by polyethylene glycol polymers were used to bind to two sites at once, creating a ligand across rat olfactory channels and bovine photoreceptor rods and, finally, protein kinase G. Identifying ligands that can bind to multiple substrate sites with high potency and specificity could open a new approach in pharmacological research.