Report

Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex

Science  20 Nov 1998:
Vol. 282, Issue 5393, pp. 1504-1508
DOI: 10.1126/science.282.5393.1504

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

Sensory experience in early life shapes the mammalian brain. An impairment in the activity-dependent refinement of functional connections within developing visual cortex was identified here in a mouse model. Gene-targeted disruption of one isoform of glutamic acid decarboxylase prevented the competitive loss of responsiveness to an eye briefly deprived of vision, without affecting cooperative mechanisms of synapse modification in vitro. Selective, use-dependent enhancement of fast intracortical inhibitory transmission with benzodiazepines restored plasticity in vivo, rescuing the genetic defect. Specific networks of inhibitory interneurons intrinsic to visual cortex may detect perturbations in sensory input to drive experience-dependent plasticity during development.

  • * To whom correspondence should be addressed. E-mail: hensch{at}postman.riken.go.jp

View Full Text

Cited By...