PerspectiveAMERSHAM PHARMACIA BIOTECH & SCIENCE PRIZE

The Rotary Enzyme of the Cell: The Rotation of F1-ATPase

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Science  04 Dec 1998:
Vol. 282, Issue 5395, pp. 1844-1845
DOI: 10.1126/science.282.5395.1844

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Summary

The winner of this year's Amersham Pharmacia Biotech & Science Prize is Hiroyuki Noji, from Japan. In his winning essay , Noji describes his thesis experiments in which he visualized the rotation of the gamma subunit of F1-ATPase by attaching long actin molecules. This result proved that the gamma subunit does indeed rotate within the bearing-like structure created by the alpha and beta subunits. F1-ATPase is a true molecular motor, converting chemical to mechanical energy on a very small scale.