KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M-Channel

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Science  04 Dec 1998:
Vol. 282, Issue 5395, pp. 1890-1893
DOI: 10.1126/science.282.5395.1890

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The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.

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