dMi-2, a Hunchback-Interacting Protein That Functions in Polycomb Repression

Science  04 Dec 1998:
Vol. 282, Issue 5395, pp. 1897-1900
DOI: 10.1126/science.282.5395.1897

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Early in Drosophila embryogenesis, gap gene products directly repress transcription of homeotic (HOX) genes and thereby delimit HOX expression domains. Subsequently, Polycomb-group proteins maintain this repression. Currently, there is no known molecular link between gap and Polycomb-group proteins. Here, dMi-2 is identified as a protein that binds to a domain in the gap protein Hunchback that is specifically required for the repression of HOX genes. Genetic analyses show that dMi-2 participates in both Hunchback and Polycomb repression in vivo. Hence, recruitment of dMi-2 may serve as a link between repression of HOX genes by Hunchback and Polycomb proteins.

  • * These two authors made equal contributions to this work.

  • Present address: School of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.

  • Present address: Max-Planck-Institut für Entwicklungsbiologie, Spemannstrasse 35/III, 72076 Tübingen, Germany.

  • § To whom correspondence should be addressed. E-mail juerg.mueller{at}

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