Special Reviews

Zinc Fingers in Caenorhabditis elegans: Finding Families and Probing Pathways

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Science  11 Dec 1998:
Vol. 282, Issue 5396, pp. 2018-2022
DOI: 10.1126/science.282.5396.2018

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More than 3 percent of the protein sequences inferred from theCaenorhabditis elegans genome contain sequence motifs characteristic of zinc-binding structural domains, and of these more than half are believed to be sequence-specific DNA-binding proteins. The distribution of these zinc-binding domains among the genomes of various organisms offers insights into the role of zinc-binding proteins in evolution. In addition, the complete genome sequence ofC. elegans provides an opportunity to analyze, and perhaps predict, pathways of transcriptional regulation.

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