T Cells On

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Science  18 Dec 1998:
Vol. 282, Issue 5397, pp. 2149
DOI: 10.1126/science.282.5397.2149l

T cells become activated after they meet their antigen, but the most efficient and persistent signaling requires costimulation of a T cell needs through another receptor, such as CD28. Wülfing and Davis (p. 2266) determined that only when the T cell antigen receptor (TCR) of T cells binds antigen while simultaneously receiving a costimulatory signal, do other proteins that are linked to the actin cytoskeleton move to the TCR complex. This costimulation-dependent cellular reorganization relies upon myosin motors and may be a key component of the costimulatory effect.

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