Source of Resistance

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Science  18 Dec 1998:
Vol. 282, Issue 5397, pp. 2149
DOI: 10.1126/science.282.5397.2149r

A subset of human tumors are resistant to the growth inhibitory effects of transforming growth factor-β (TGF-β). An understanding of the molecular mechanisms underlying this resistance may provide new insights into tumorigenesis. In a study of cultured cells, Sun et al. (p. 2270) found that TGF-β resistance can be conferred by overexpression of MDM2, an oncoprotein shown previously to interact with the p53 tumor suppressor. MDM2 appears to mediate resistance by interfering with signaling by the Rb/E2F transcription factor complex.

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