The Hippocampus and Human Navigation

Science  18 Dec 1998:
Vol. 282, Issue 5397, pp. 2149
DOI: 10.1126/science.282.5397.2149t

E. A. Maguire et al. (Reports, 8 May, p. 921) investigated “the neural basis of navigation by humans … with functional neuroimaging of brain activity during navigation in a familiar, yet complex virtual reality town.” One finding was that accurate navigation was associated with activation of the right hippocampus.

I. Fried comments that such activation is “primarily outside the hippocampus” according to the figures and stereotactic coordinates provided in the report. He notes that other recent studies have found such activity to be associated with the para hippocampus.

In response, Maguire discusses the brain coordinate system and template used in the report and provides a figure showing “the location of the peaks of activity for the two relevant activations,” which falls within “the subicular regions of the hippocampal formation.” The full text of these comments can be seen at

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