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Science  18 Dec 1998:
Vol. 282, Issue 5397, pp. 2149
DOI: 10.1126/science.282.5397.2149g

Auxins, hormones that regulate many developmental processes in plants, are transported from the tip of the plant to other tissues. Continuing on hypotheses first proposed by Darwin, researchers have long been in search of the molecules responsible for the directed transport. Gälweiler et al. (p. 2226; see the Perspective by Jones) have now cloned the AtPIN1 gene from Arabidopsis. Mutants defective in PIN1 are deficient in auxin transport. The protein product, whose predicted sequence shows similarity to bacterial carrier proteins, is located at the basal ends of cells involved in auxin transport, thus providing insight into the molecular basis of unidirectional auxin transport.

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