Pumping Iron Through Cell Membranes

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Science  18 Dec 1998:
Vol. 282, Issue 5397, pp. 2202-2203
DOI: 10.1126/science.282.5397.2202

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Despite their importance in various cellular functions, the three-dimensional structure at atomic resolution has been determined for only a few membrane proteins. In his Perspective, Braun discusses results reported in the same issue by Ferguson et al. in which the crystal structure of FhuA, an iron transporter protein, has been determined at high resolution. This and related proteins may be the general model for a large class of iron-transporting molecules.

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