A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

See allHide authors and affiliations

Science  18 Dec 1998:
Vol. 282, Issue 5397, pp. 2266-2269
DOI: 10.1126/science.282.5397.2266

You are currently viewing the abstract.

View Full Text


During T cell activation, the engagement of costimulatory molecules is often crucial to the development of an effective immune response, but the mechanism by which this is achieved is not known. Here, it is shown that beads attached to the surface of a T cell translocate toward the interface shortly after the start of T cell activation. This movement appears to depend on myosin motor proteins and requires the engagement of the major costimulatory receptor pairs, B7-CD28 and ICAM-1–LFA-1. This suggests that the engagement of costimulatory receptors triggers an active accumulation of molecules at the interface of the T cell and the antigen-presenting cell, which then increases the overall amplitude and duration of T cell signaling.

View Full Text