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CD1d-Restricted Immunoglobulin G Formation to GPI-Anchored Antigens Mediated by NKT Cells

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Science  08 Jan 1999:
Vol. 283, Issue 5399, pp. 225-229
DOI: 10.1126/science.283.5399.225

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Abstract

Immunoglobulin G (IgG) responses require major histocompatibility complex (MHC)–restricted recognition of peptide fragments by conventional CD4+ helper T cells. Immunoglobulin G responses to glycosylphosphatidylinositol (GPI)- anchored protein antigens, however, were found to be regulated in part through CD1d-restricted recognition of the GPI moiety by thymus-dependent, interleukin-4–producing CD4+, natural killer cell antigen 1.1 [(NK1.1)+] helper T cells. The CD1-NKT cell pathway regulated immunogobulin G responses to the GPI-anchored surface antigens of Plasmodium andTrypanosoma and may be a general mechanism for rapid, MHC-unrestricted antibody responses to diverse pathogens.

  • * To whom correspondence should be addressed. E-mail: schofield{at}wehi.edu.au

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