News of the WeekAids

T Cell Production Slowed, Not Exhausted?

See allHide authors and affiliations

Science  15 Jan 1999:
Vol. 283, Issue 5400, pp. 305-306
DOI: 10.1126/science.283.5400.305a

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Does the AIDS virus cause the disease's signature symptom--the progressive loss of CD4 T lymphocytes, the primary immune cell targeted by HIV--by destroying T cells so quickly and efficiently that the immune system exhausts itself trying to replace them, or does it disrupt the immune system's ability to produce T cells in the first place? In the January issue of Nature Medicine, a team reports results obtained by using a new technique that for the first time provides a direct measure of how many new cells are produced over a given time period. The findings, the team says, support the notion that HIV's most important and insidious talent is to interfere with T cell production.