Research Article

Fusion-Competent Vaccines: Broad Neutralization of Primary Isolates of HIV

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Science  15 Jan 1999:
Vol. 283, Issue 5400, pp. 357-362
DOI: 10.1126/science.283.5400.357

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Current recombinant human immunodeficiency virus (HIV) gp120 protein vaccine candidates are unable to elicit antibodies capable of neutralizing infectivity of primary isolates from patients. Here, “fusion-competent” HIV vaccine immunogens were generated that capture the transient envelope-CD4-coreceptor structures that arise during HIV binding and fusion. In a transgenic mouse immunization model, these formaldehyde-fixed whole-cell vaccines elicited antibodies capable of neutralizing infectivity of 23 of 24 primary HIV isolates from diverse geographic locations and genetic clades A to E. Development of these fusion-dependent immunogens may lead to a broadly effective HIV vaccine.

  • * Present address: Oregon Health Sciences University, Portland, OR 97201, USA.

  • To whom correspondence should be addressed. E-mail: nunberg{at}

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