Against Antibiotic Resistance

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Science  29 Jan 1999:
Vol. 283, Issue 5402, pp. 601p
DOI: 10.1126/science.283.5402.601p

The ability of staphylococci to resist β-lactam antibiotics took away a powerful weapon against disease. Rosen et al. (p. 703) present a solution to the problem by redesigning an antibiotic so that it has strong antibacterial activity against resistant organisms but can release a side chain that had been causing animals to develop an immune response that would make the antibiotic toxic.

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