Costimulation: Building an Immunological Synapse

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Science  29 Jan 1999:
Vol. 283, Issue 5402, pp. 649-650
DOI: 10.1126/science.283.5402.649

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Immune responses are triggered by activation of the T cell receptor with foreign antigen. Dustin summarizes in his Perspective new evidence that this triggering event is actually the formation of an "immunological synapse," an area of close contact between cells. Recent results ( Viola et al. in this issue) begin to characterize the process by which this structure is formed and define its components.