PerspectiveSignal Transduction

The Path to Specificity

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Science  29 Jan 1999:
Vol. 283, Issue 5402, pp. 650-651
DOI: 10.1126/science.283.5402.650

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A major challenge in the study of intracellular signaling has been the elucidation of the physical and biological principles by which the network of signaling molecules is assembled to execute signaling programs. In their Perspective, Zuker et al. address recent work focusing on the organization of signaling components into macromolecular assemblies, in particular, the tyrosine kinase and G protein-coupled receptor pathways.