Report

Coordinated Regulation of Iron-Controlling Genes, H-Ferritin and IRP2, by c-MYC

Science  29 Jan 1999:
Vol. 283, Issue 5402, pp. 676-679
DOI: 10.1126/science.283.5402.676

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Abstract

The protein encoded by the c-MYC proto-oncogene is a transcription factor that can both activate and repress the expression of target genes, but few of its transcriptional targets have been identified. Here, c-MYC is shown to repress the expression of the heavy subunit of the protein ferritin (H-ferritin), which sequesters intracellular iron, and to stimulate the expression of the iron regulatory protein–2 (IRP2), which increases the intracellular iron pool. Down-regulation of the expression of H-ferritin gene was required for cell transformation by c-MYC. These results indicate that c-MYC coordinately regulates genes controlling intracellular iron concentrations and that this function is essential for the control of cell proliferation and transformation by c-MYC.

  • * To whom correspondence should be addressed. E-mail: rd10{at}columbia.edu

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