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Oligomeric Structure of the Human EphB2 Receptor SAM Domain

Science  05 Feb 1999:
Vol. 283, Issue 5403, pp. 833-836
DOI: 10.1126/science.283.5403.833

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Abstract

The sterile alpha motif (SAM) domain is a protein interaction module that is present in diverse signal-transducing proteins. SAM domains are known to form homo- and hetero-oligomers. The crystal structure of the SAM domain from an Eph receptor tyrosine kinase, EphB2, reveals two large interfaces. In one interface, adjacent monomers exchange amino-terminal peptides that insert into a hydrophobic groove on each neighbor. A second interface is composed of the carboxyl-terminal helix and a nearby loop. A possible oligomer, constructed from a combination of these binding modes, may provide a platform for the formation of larger protein complexes.

  • * To whom correspondence should be addressed. E-mail: bowie{at}mbi.ucla.edu

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