Control of Viremia in Simian Immunodeficiency Virus Infection by CD8+ Lymphocytes

Science  05 Feb 1999:
Vol. 283, Issue 5403, pp. 857-860
DOI: 10.1126/science.283.5403.857

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Clinical evidence suggests that cellular immunity is involved in controlling human immunodeficiency virus–1 (HIV-1) replication. An animal model of acquired immune deficiency syndrome (AIDS), the simian immunodeficiency virus (SIV)–infected rhesus monkey, was used to show that virus replication is not controlled in monkeys depleted of CD8+ lymphocytes during primary SIV infection. Eliminating CD8+ lymphocytes from monkeys during chronic SIV infection resulted in a rapid and marked increase in viremia that was again suppressed coincident with the reappearance of SIV-specific CD8+ T cells. These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses.

  • * To whom correspondence should be addressed. E-mail: jschmitz{at}; kreimann{at}

  • Present address: Bristol-Myers Squibb, PRI, Department of Experimental Pathology, Princeton, NJ 08540, USA.

  • Present address: Cambridge Pharma Consultancy, North America Office, New York, NY 10022.

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