Proteasome Partner

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Science  12 Feb 1999:
Vol. 283, Issue 5404, pp. 901k
DOI: 10.1126/science.283.5404.901k

Proteasomes degrade cellular proteins and thus contribute to the regulation of the life-span of many proteins and also provide a source of peptides for class I major histocompatibility proteins. Geier et al. (p. 978) found that mammalian cell lines contain another large structure in their cytoplasm that can degrade proteins. Fifty-nanometer-long rods comprised of only tripeptidyl peptidase II (TPPII) had both exo- and endoproteolytic activity. These complexes may contribute to the cell's survival when proteasomes are inactivated.

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