T Cells and Dendritic Cells Get Intimate

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Science  19 Feb 1999:
Vol. 283, Issue 5405, pp. 1124-1125
DOI: 10.1126/science.283.5405.1124

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Dendritic cells (DCs) are capable of both antigen presentation and CD4 T cell activation. A study in this week's issue by Rissoan and colleagues, discussed in the Perspective by Bottomly, now shows one way in which DCs determine the selectivity of the T cell immune response. Myeloid-like DCs produce interleukin-12, which skews T cell differentiation toward a T helper 1 (T1) response, whereas lymphoid-like DCs favor a T2 response.