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Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

Science  19 Feb 1999:
Vol. 283, Issue 5405, pp. 1183-1186
DOI: 10.1126/science.283.5405.1183

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Abstract

It is not known whether subsets of dendritic cells provide different cytokine microenvironments that determine the differentiation of either type-1 T helper (TH1) or TH2 cells. Human monocyte (pDC1)–derived dendritic cells (DC1) were found to induce TH1 differentiation, whereas dendritic cells (DC2) derived from CD4+CD3CD11cplasmacytoid cells (pDC2) induced TH2 differentiation by use of a mechanism unaffected by interleukin-4 (IL-4) or IL-12. The TH2 cytokine IL-4 enhanced DC1 maturation and killed pDC2, an effect potentiated by IL-10 but blocked by CD40 ligand and interferon-γ. Thus, a negative feedback loop from the mature T helper cells may selectively inhibit prolonged TH1 or TH2 responses by regulating survival of the appropriate dendritic cell subset.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: yliu{at}dnax.org

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