Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

Science  19 Feb 1999:
Vol. 283, Issue 5405, pp. 1183-1186
DOI: 10.1126/science.283.5405.1183

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


It is not known whether subsets of dendritic cells provide different cytokine microenvironments that determine the differentiation of either type-1 T helper (TH1) or TH2 cells. Human monocyte (pDC1)–derived dendritic cells (DC1) were found to induce TH1 differentiation, whereas dendritic cells (DC2) derived from CD4+CD3CD11cplasmacytoid cells (pDC2) induced TH2 differentiation by use of a mechanism unaffected by interleukin-4 (IL-4) or IL-12. The TH2 cytokine IL-4 enhanced DC1 maturation and killed pDC2, an effect potentiated by IL-10 but blocked by CD40 ligand and interferon-γ. Thus, a negative feedback loop from the mature T helper cells may selectively inhibit prolonged TH1 or TH2 responses by regulating survival of the appropriate dendritic cell subset.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: yliu{at}

View Full Text

Cited By...