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Chlamydia Infections and Heart Disease Linked Through Antigenic Mimicry

Science  26 Feb 1999:
Vol. 283, Issue 5406, pp. 1335-1339
DOI: 10.1126/science.283.5406.1335

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Abstract

Chlamydia infections are epidemiologically linked to human heart disease. A peptide from the murine heart muscle–specific α myosin heavy chain that has sequence homology to the 60-kilodalton cysteine-rich outer membrane proteins of Chlamydia pneumoniae, C. psittaci, and C. trachomatiswas shown to induce autoimmune inflammatory heart disease in mice. Injection of the homologous Chlamydia peptides into mice also induced perivascular inflammation, fibrotic changes, and blood vessel occlusion in the heart, as well as triggering T and B cell reactivity to the homologous endogenous heart muscle–specific peptide.Chlamydia DNA functioned as an adjuvant in the triggering of peptide-induced inflammatory heart disease. Infection with C. trachomatis led to the production of autoantibodies to heart muscle–specific epitopes. Thus, Chlamydia-mediated heart disease is induced by antigenic mimicry of a heart muscle–specific protein.

  • * To whom correspondence should be addressed. E-mail: jpenning{at}amgen.com

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