Adhesive and Mammalian Transglutaminase Substrate Properties of Candida albicans Hwp1

Science  05 Mar 1999:
Vol. 283, Issue 5407, pp. 1535-1538
DOI: 10.1126/science.283.5407.1535

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


The pathogenesis of candidiasis involves invasion of host tissues by filamentous forms of the opportunistic yeast Candida albicans. Morphology-specific gene products may confer proinvasive properties. A hypha-specific surface protein, Hwp1, with similarities to mammalian small proline-rich proteins was shown to serve as a substrate for mammalian transglutaminases. Candida albicansstrains lacking Hwp1 were unable to form stable attachments to human buccal epithelial cells and had a reduced capacity to cause systemic candidiasis in mice. This represents a paradigm for microbial adhesion that implicates essential host enzymes.

  • * Present address: Grays Harbor Dental Specialists, 105 South Broadway, Aberdeen, WA 98520, USA.

  • To whom correspondence should be addressed. E-mail: sundstrom.1{at}

View Full Text

Cited By...