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Adhesive and Mammalian Transglutaminase Substrate Properties of Candida albicans Hwp1

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Science  05 Mar 1999:
Vol. 283, Issue 5407, pp. 1535-1538
DOI: 10.1126/science.283.5407.1535

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Abstract

The pathogenesis of candidiasis involves invasion of host tissues by filamentous forms of the opportunistic yeast Candida albicans. Morphology-specific gene products may confer proinvasive properties. A hypha-specific surface protein, Hwp1, with similarities to mammalian small proline-rich proteins was shown to serve as a substrate for mammalian transglutaminases. Candida albicansstrains lacking Hwp1 were unable to form stable attachments to human buccal epithelial cells and had a reduced capacity to cause systemic candidiasis in mice. This represents a paradigm for microbial adhesion that implicates essential host enzymes.

  • * Present address: Grays Harbor Dental Specialists, 105 South Broadway, Aberdeen, WA 98520, USA.

  • To whom correspondence should be addressed. E-mail: sundstrom.1{at}osu.edu

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