Deconstructing DNA for Faster Sequencing

+ See all authors and affiliations

Science  12 Mar 1999:
Vol. 283, Issue 5408, pp. 1669
DOI: 10.1126/science.283.5408.1669

You are currently viewing the summary.

View Full Text


At the heart of the international race to sequence the human genome are machines that create thousands of copies of DNA fragments as a first step toward decoding their sequence, one nucleotide base pair at a time. But a handful of groups around the world are working on new approaches that decode single copies of DNA directly using molecular probes--approaches which have the potential to simplify and speed up the sequencing process.