Deconstructing DNA for Faster Sequencing

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Science  12 Mar 1999:
Vol. 283, Issue 5408, pp. 1669
DOI: 10.1126/science.283.5408.1669

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At the heart of the international race to sequence the human genome are machines that create thousands of copies of DNA fragments as a first step toward decoding their sequence, one nucleotide base pair at a time. But a handful of groups around the world are working on new approaches that decode single copies of DNA directly using molecular probes--approaches which have the potential to simplify and speed up the sequencing process.