Truncated RanGAP Encoded by the Segregation Distorter Locus of Drosophila

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Science  12 Mar 1999:
Vol. 283, Issue 5408, pp. 1742-1745
DOI: 10.1126/science.283.5408.1742

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Segregation Distorter (SD) inDrosophila melanogaster is a naturally occurring meiotic drive system in which the SD chromosome is transmitted fromSD/SD+ males in vast excess over its homolog owing to the induced dysfunction of SD+-bearing spermatids. The Sd locus is the key distorting gene responsible for this phenotype. A genomic fragment from theSd region conferred full distorting activity when introduced into the appropriate genetic background by germline transformation. The only functional product encoded by this fragment is a truncated version of the RanGAP nuclear transport protein. These results demonstrate that this mutant RanGAP is the functional Sd product.

  • * Present address: Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.

  • To whom correspondence should be addressed. E-mail: ganetzky{at}

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