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Signaling of Cell Fate Decisions by CLAVATA3 in Arabidopsis Shoot Meristems

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Science  19 Mar 1999:
Vol. 283, Issue 5409, pp. 1911-1914
DOI: 10.1126/science.283.5409.1911

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Abstract

In higher plants, organogenesis occurs continuously from self-renewing apical meristems. Arabidopsis thaliana plants with loss-of-function mutations in the CLAVATA (CLV1,2, and 3) genes have enlarged meristems and generate extra floral organs. Genetic analysis indicates that CLV1, which encodes a receptor kinase, acts with CLV3 to control the balance between meristem cell proliferation and differentiation.CLV3 encodes a small, predicted extracellular protein.CLV3 acts nonautonomously in meristems and is expressed at the meristem surface overlying the CLV1 domain. These proteins may act as a ligand-receptor pair in a signal transduction pathway, coordinating growth between adjacent meristematic regions.

  • * Present address: University of California Berkeley, U.S. Department of Agriculture–Agricultural Research Service Plant Gene Expression Center, 800 Buchanan Street, Albany, CA 94710, USA.

  • To whom correspondence should be addressed at Division of Biology 156-29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. E-mail: meyerow{at}cco.caltech.edu

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