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Crystal Structure of Human ZAG, a Fat-Depleting Factor Related to MHC Molecules

Science  19 Mar 1999:
Vol. 283, Issue 5409, pp. 1914-1919
DOI: 10.1126/science.283.5409.1914

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Abstract

Zn-α2-glycoprotein (ZAG) is a soluble protein that is present in serum and other body fluids. ZAG stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. The 2.8 angstrom crystal structure of ZAG resembles a class I major histocompatibility complex (MHC) heavy chain, but ZAG does not bind the class I light chain β2-microglobulin. The ZAG structure includes a large groove analogous to class I MHC peptide binding grooves. Instead of a peptide, the ZAG groove contains a nonpeptidic compound that may be implicated in lipid catabolism under normal or pathological conditions.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: bjorkman{at}cco.caltech.edu

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