PerspectiveSignal Transduction

Crosstalk Between Rac and Rho

Science  26 Mar 1999:
Vol. 283, Issue 5410, pp. 2028-2029
DOI: 10.1126/science.283.5410.2028

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Summary

Cell motility is the result of a delicate balance between the activities of Rac, Cdc42, and RhoA, members of the Rho family of guanine nucleotide triphosphatases that are important regulators of the cell cytoskeleton. In his Perspective, Burridge discusses the report by Sanders et al. in this issue, which implicates p21-activated kinase (PAK) in a pathway that counteracts the contractility induced by RhoA. PAK (which is activated by Rac or Cdc42) blocks myosin light chain phosphorylation, resulting in a decrease in myosin activity, which in turn reduces cell contractility.

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