Report

Requirement of Type III TGF-β Receptor for Endocardial Cell Transformation in the Heart

See allHide authors and affiliations

Science  26 Mar 1999:
Vol. 283, Issue 5410, pp. 2080-2082
DOI: 10.1126/science.283.5410.2080

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

Transforming growth factor–β (TGF-β) signaling is mediated by a complex of type I (TBRI) and type II (TBRII) receptors. The type III receptor (TBRIII) lacks a recognizable signaling domain and has no clearly defined role in TGF-β signaling. Cardiac endothelial cells that undergo epithelial-mesenchymal transformation express TBRIII, and here TBRIII-specific antisera were found to inhibit mesenchyme formation and migration in atrioventricular cushion explants. Misexpression of TBRIII in nontransforming ventricular endothelial cells conferred transformation in response to TGF-β2. These results support a model where TBRIII localizes transformation in the heart and plays an essential, nonredundant role in TGF-β signaling.

  • * To whom correspondence should be addressed. E-mail: joey.barnett{at}mcmail.vanderbilt.edu

View Full Text